Antonelli will line up from pole position for the 52-lap race having already won the sprint earlier on Saturday.
Clark called last year’s incident at Oakmont the “lowest point” of his career.
Gregor Townsend’s side have now won four of their six Tests this calendar year.
The all-rounder played a starring role in Saturday’s T20 victory over India.
John and Thady Gosden-trained grey won last year’s Irish 2000 Guineas and St James’s Palace Stakes.